Direct Relief Ranked 5th Largest Charity in the U.S. by Forbes

Monoclonal antibody therapies, donated by Eli Lilly and Company, are packed inside cold storage shippers on June 25, 2021, in preparation for shipment to communities impacted by Covid-19. The therapies can be used to treat mild to moderate cases of Covid-19. (Lara Cooper/Direct Relief)

Direct Relief was the fifth largest charity in the United States in 2021, according to Forbes Magazine’s newly released annual list of the 100 largest U.S. charities ranked by private donations. The humanitarian medical aid group received $1.9 billion in private donations in its 2021 fiscal year.

Among the ten largest charities in the Forbes 2021 ranking, Direct Relief is the only one to receive a score of 100% for both charitable commitment (how much of a charity’s total expense go directly to the charitable purpose) and 100% on fundraising efficiency (the percent of private donations remaining after deducting fundraising costs).

Direct Relief is one of the world’s largest channels for humanitarian medical assistance to underserved communities and victims of disasters.

In Calendar Year 2021, Direct Relief has:

Among the 160,000 non-profits rated by Charity Navigator in 2021, Direct Relief is one of the 92 on the current “Perfect 100” list of charities earning scores of 100 in both the Financial and Accountability & Transparency categories.

“The acute new health challenges that Covid brought on for everyone made all the existing challenges that much worse—particularly for people and places most vulnerable and least fortunate,” said Thomas Tighe, Direct Relief President and CEO. “Direct Relief has and will continue to stretch every dollar to help in the most efficient, productive way possible.”

Direct Relief is supported only by private, charitable contributions, accepting no government funding. The vast majority of the value of donations received and aid distributed is in the form of medicine and medical supplies donated by their manufacturers (in-kind contributions). Direct Relief values donated medicine and supplies at wholesale value; see for more information.

The complete list of Forbes’s ratings and its methodology for America’s Top Charities 2021 is available at

To learn more, please read the Direct Relief 2021 Impact Report.

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